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• hypersensitivity to the components of the drug;
• age up to 3 years;
• period of pregnancy;
• lactose intolerance;
• lactase deficiency;
• intolerance to glucose and galactose.

Dosage and administration

For flu, colds and other acute respiratory infections, take two tablets. 3 times a day for the first 2 days, then one tablet 3 times a day. The duration of the course is 4 days.

For the prevention of influenza, colds and other acute respiratory infections, 2 tablets are prescribed. 1 time per day for 7 days. Then spend a 5-day break, after which, if necessary, the 7-day cycle is repeated. The duration of the prophylactic course is determined by the attending physician, and ranges from 7 days to 3-5 months.

For the treatment of herpes virus infection, take 2 tablets. 3 times a day. The duration of the course is 5 days.

For flu, colds and other acute respiratory infections, take 1 table. 2 times a day for two days, then 1 table. per day. The duration of the course is 4 days.

For flu, colds and other acute respiratory infections, take 1 table. 3 times a day for two days, then 1 table. 2 times a day.

For the prevention of influenza, colds and other acute respiratory infections, 2 tablets are prescribed. 1 time per day for a week. Then spend a 5-day break, after which the 7-day cycle is repeated. The duration of prophylaxis depends on various factors, and is determined by the attending physician. Prevention lasts from 7 days to 3-5 months.

Overdose

Side effects

Interaction with other drugs

special instructions

Storage conditions

Bird flu

Kagocel for children

Evaluation of the effectiveness of herpes treatment

Evaluation of the effectiveness of the treatment of acute respiratory viral infections in children

• when using the drug in children, regardless of the characteristics of the course of ARVI, the duration of its symptoms is reduced;
• the drug increases interferon levels in children with initially insufficient levels;
• there are no side effects associated with the use of the drug in children;

Kagocel is well tolerated by children and reduces the duration of the disease.

Reviews

Kagocel is an interferon inducer, that is, it stimulates or provokes its release. This antiviral agent is prescribed for many diseases, including influenza. However, the influenza virus has a special gene that can inhibit the release of interferon in the cell. Why, in this case, take a medicine that obviously will not help? To get rid of money? There are also medicines that contain interferon, which will certainly help with the flu - for example, viferon.

I did not drink this drug for the flu. In that season, a small herpes broke out - so I did not understand whether Kagocel worked, or the remission came on its own. It would be better to spend money on acyclovir ointment - it obviously helps faster.

After reading some of the reviews, I would like to comment on something. I think it's good medicinal product it is highly doubtful if the temperature returned to normal from 38.5 in 3-4 days. Most likely there is a natural recovery, which occurs without such drugs. I think the drug is effective only with certain strains of viruses, and the advertising campaign that has now unfolded around it is not justified.

A month ago I came down with the flu. The temperature rose to 38.5, and antipyretics practically did not help. My doctor prescribed Kagocel (apparently the advertisement worked). The medicine, meanwhile, is quite expensive - 12 tablets (and they are tiny) cost 230 rubles. A course of treatment requires two packs. The pharmacist at the pharmacy confirmed that this drug should help with the flu. So I bought the package to get started. I started drinking two tablets at once, 3 times a day for the first three days, as indicated in the manual, well, as the doctor prescribed. The effect was felt quite quickly - the antipyretic began to act, the temperature dropped to 37.5. But such hyperthermia also causes concern, and the effect did not last long. After 2-3 hours the temperature began to increase again, and rose to 38.5. In the end, I decided to buy antibiotics for 15 rubles, and began to drink in combination with Kagocel. For 3 days of treatment with antibiotics, the temperature dropped to 37.1, and then completely returned to normal. So, from my own experience, I can say that Kagocel is an ineffective medicine. I advise you not to pay attention to advertising, and not to be led by narrow-minded doctors. Antibiotics, of course, are harmful in their own way, but they are, in any case, reliable. I wish you all good health.

I got sick right before going to the theatre. All the signs of a cold appeared - sneezing, itching in the throat, rhinitis, temperature over 37. Still, we decided to go to the theater, so I bought a package of Kagocel. Just in that season, it was advertised wherever possible. Before that, I had not met him. I took it according to the scheme in the instructions, the next day it didn’t get any better, but it didn’t get worse either. But on the 3rd day I woke up fresh and full of strength - a runny nose and sore throat were gone. I drank the medicine at the previous dosage - and everything is normal. It could be assumed that she herself recovered, but the fact is that I usually get sick for at least a week. But in subsequent cases, when I again decided to take it for a cold, it did not work at all. Maybe he somehow softened the course of the disease, but somehow imperceptibly.

I also read in the instructions that it treats herpes. When I get sick, this muck constantly pops up on my lips. So this vaunted drug never helped, anyway, herpes crawled out during the illness.

I think that kagocel helps only the first time, when the body is still sensitive to it, and only then does it really help with colds.

I had a case that allowed me to test the antiviral effect of Kagocel in practice. Since most medications are contraindicated during breastfeeding, I had to limit myself to them only. It stimulates the production of interferon (a protein that protects against viruses) in all cells of the body. Many other drugs work on the same principle. I chose between arbidol and kagocel, and decided to be treated with the second, because. on the 1st day, you need to take 6 tablets of Kagocel or 8 of Arbidol. And since they are about the same price, the second one was cheaper.

The first day of treatment, I hardly got out of bed, the temperature kept, the runny nose was terrible, tears flowed from my eyes, I sneezed constantly. But on the second day I was already doing housework, and still had time to look after the child. On the third day I woke up with a feeling of complete recovery. I don't remember ever recovering so quickly before. Mom, by the way, also recovered in almost 2 days - she advised me Kagocel.

I don’t want to remember how I used to be treated without Kagocel. Unlike various anti-influenza drugs (Rinza, Theraflu, etc.), which simply treat the symptoms and not the disease, Kagocel causes the body to produce the antiviral protein interferon, that is, it strengthens the body in the fight against the virus. The only subtlety is that it is necessary to start treatment in a timely manner, no later than the 2nd day from the onset of the disease, ideally at the first manifestations. I easily determine the onset of the disease - I immediately begin to sneeze. Now, as soon as I feel that I get sick, I drink 2 tablets - and in the morning I feel great. True, I missed time once and started treatment only on the 3rd day. Given that it was the flu, I recovered after two days. But, in any case, it is faster than when taking the above symptomatic remedies.

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Reviews

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Kagocel /

Antiviral drug. interferon synthesis inductor. The active substance is the sodium salt of the copolymer of (1→4)-6-0-carboxymethyl-β-D-glucose, (1→4)-β-D-glucose and (21→24)-2,3,14,15 ,21,24,29,32-octahydroxy-23-(carboxymethoxymethyl)-7,10-dimethyl-4, 13-di(2-propyl)-19,22,26,30,31-pentaoxaheptacyclo dotriaconta-1,3 ,5(28),6,8(27), 9(18),10, 12(17), 13,15-decane.

It causes the formation in the body of the so-called late interferon, which is a mixture of alpha and beta interferons with high antiviral activity. Kagocel® causes the production of interferon in almost all cell populations involved in the antiviral response of the body: T- and B-lymphocytes, macrophages, granulocytes, fibroblasts, endothelial cells. When a single dose of Kagocel® is taken orally, the interferon titer in blood serum reaches its maximum values ​​after 48 hours. The dynamics of interferon accumulation in the intestine when the drug is taken orally does not coincide with the dynamics of titers of circulating interferon. In blood serum, the level of interferon reaches high values ​​only 48 hours after taking Kagocel®, while in the intestines, the maximum production of interferon is noted already after 4 hours.

The greatest efficiency in the treatment with Kagocel® is achieved when it is prescribed no later than the 4th day from the onset of an acute infection. For prophylactic purposes, the drug can be used at any time, incl. and immediately after contact with the infectious agent

For the treatment of influenza and SARS, it is prescribed in the first 2 days - 2 tab. 3 times / day, in the next 2 days - 1 tab. 3 times / day. In total, for a course lasting 4 days - 18 tab.

Prevention of influenza and SARS is carried out in 7-day cycles: 2 days - 2 tab. 1 time / day, break for 5 days. Then the cycle is repeated. The duration of the prophylactic course varies from 1 week to several months.

For the treatment of herpes, 2 tablets are prescribed. 3 times / day for 5 days. Total for a course lasting 5 days - 30 tab.

For the treatment of influenza and SARS, it is prescribed in the first 2 days - 1 tab. 3 times / day, in the next 2 days - 1 tab. 2 times/day In total, for a course lasting 4 days - 10 tab.

Prevention of influenza and SARS is carried out in 7-day cycles: 2 days - 1 tab. 1 time / day, break for 5 days, then repeat the cycle. The duration of the prophylactic course is from 1 week to several months.

What is dangerous kagocel

Is the well-known medicine Kagocel effective and can it be dangerous?

Of course, each of us needs a good, effective medicine in case of a cold. But I, as a specialist, can say that the effect of well-known antiviral drugs that currently exist on the Russian market is very small. Many compatriots buy into advertising and purchase the dubious Kagocel drug. I would like to warn citizens against this medicine and clarify some of the nuances.

Research: is Kagocel effective?

How are drugs tested for effectiveness? For this, there are comparative clinical trials (CTs). During their conduct, experts compare which patients are more likely to recover: those who took this or that drug, or those who took a placebo. The sample of patients should be representative. Such clinical trials are called randomized trials (RCTs).

In developed countries, drugs that have not undergone this kind of research are not released to the market. The effectiveness of a drug is determined by the RCTs, and not by the Ministry of Health, therefore, manufacturers of many well-known drugs (Arbidol, Actovegin, Cerebrolysin, etc.) conduct studies to prove the safety and effectiveness of the drugs produced.

What do the Kagocel RCTs show? The American database MEDLINE, which can be accessed by anyone on the Internet on the website of the US National Library of Medicine, provides benign information. In the search engine at pubmed.gov, enter the phrase "kagocel AND randomized controlled trial". This way you will select all publications mentioning "Kagocel" and at the same time - all publications about RCT. None of the 12 articles that are registered in the database contains a single mention of the Kagocel RCT.

In some domestic minor scientific journals, however, a couple of RCTs of this drug are mentioned. The sample for conducting the studies was very small: 81 adults participated in one (Merkulova L.N. et al. F. S. et al. Clinical efficacy of Kagocel, Children's infections, 2010. (4): 1-7) - 60 children. The quality of such studies is questionable.

Let's take a closer look at them. In the first, the sampling frame was the clinical manifestations found in patients, which means that people, in addition to influenza, could have other diseases. And the report says that out of 81 people, 81 were sick with the flu - it sounds absolutely implausible. Another strange moment: patients were included in the CT in the first two days, and the data that their intoxication disappeared are given for all for the same period! Moreover, in 71 percent of patients, the temperature subsided on the same day when they came to the study.

The second study (involving children) also seems dubious, with few details. It may not be an RCT at all in the way it should be.

The Rosnano website has a list of studies whose titles look like they are RCTs, but there are no published scientific texts on the website. Moreover, there are no so-called phase three trials on this list - they are necessary in order to establish whether the drug is effective and safe for adults. What is most striking (unpleasant!) is that the lion's share of research is research on children. A frightening statistic, especially considering that the adverse effects of this drug can be irreversible. We will talk about this further.

We can make a confident conclusion that "Kagocel" is not effective tool prevention and, especially, treatment of influenza and colds.

Ministry of Health warns?

The Ministry of Health considers Kagocel an antiviral drug, which is “recommended for the treatment and prevention of SARS (acute respiratory viral infections) and influenza, as well as for the treatment of herpes.” Thus, if a healthy person drinks this medicine, he will get sick less often (prevention), and if a sick person drinks it, he will recover faster (treatment). But it is one thing to relieve the symptoms of a cold, and quite another to treat the disease. I'm not talking about the risk of complications that the flu virus can cause, or the side effects that some drugs can have on the body weakened by the infection. In published studies, there is no information about the side effects of Kagocel.

But the fact is known that the scientists who invented this medicine created a molecule from two parts - carboxymethylcellulose (CMC) and gossypol. The first is, for example, in wallpaper paste, and in large quantities. Gossypol, on the other hand, is a substance extracted from the cotton plant that negatively affects reproductive performance in both men and women. Once it was wanted to be used as a contraceptive, but due to its high toxicity, this idea was not promoted further. You can read about how poisonous gossypol is in the article by E. Ushkalova and N. Chukhareva (E. Ushkalova, N. Chukhareva. Sales leaders of over-the-counter drugs and problems of their safety. Vrach, 2014. (9)).

The manufacturers of Kagocel claim that there is no free gossypol in the drug - it is in a bound form that is safe. This is confirmed by experiments conducted on mice: in experimental animals, no pregnancy disorders were detected. But manufacturers do not provide any studies on the safety of the drug for humans. Over the years of massive sales, such studies could be done. Therefore, I believe that the question of whether Kagocel is toxic remains open.

Unverified medicine - in all pharmacies of the country

It has been proven that Kagocel promotes increased production of interferons in the human body - these are substances that cells produce in response to external aggression, to infection. This is how the body defends itself against viruses. It would seem that everything is logical - but clinical trials do not confirm this assumption. This or that medicine can help the body produce interferons, but it does not protect against infection. Why - scientists do not know. Therefore, we cannot say that Kagocel helps with colds or flu: as already mentioned, there are no confirmed RCTs.

Another question: how did the poorly tested medicine get into pharmacies and why is it being sold without a prescription? Indeed, without a doctor's referral, only safe, proven, well-studied products are sold. An even more serious question: why did Kagocel, a drug with unproven effectiveness, which, in addition, can be toxic, appear on the Russian List of Essential Drugs? However, a place on this list greatly increases the sales of the drug in all pharmacies in the country ...

IA No. FS77-55373 dated September 17, 2013, issued by the Federal Service for Supervision of Communications, Information Technology and Mass Media (Roskomnadzor). Founder: PRAVDA.Ru LLC

Antiviral drug Kagocel: pros and cons

Every fifth Russian does not have enough money to buy the necessary medicines, more than half of the country's residents assess the cost of their purchase as significant for their budget, according to a survey by VTsIOM.

Among the most popular medicines in Russia sold in pharmacies without a prescription, you can find not only absolutely useless, but also potentially harmful.

Medicines containing codeine must be sold strictly according to prescriptions, the head of the Federal Drug Control Service (FSKN) of the Russian Federation, Viktor Ivanov, demanded today.

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The site provides reference information for informational purposes only. Diagnosis and treatment of diseases should be carried out under the supervision of a specialist. All drugs have contraindications. Expert advice is required!

general information

According to the latest statistics, on average, an adult has 2 to 3 weeks of a year with a cold, flu, or acute respiratory illness. About half of this time falls on November-December. At this time of the year, the maximum spread of influenza and SARS is observed.

The pace of modern life in large cities requires a person to save time and effort. Undoubtedly, the above diseases have a very adverse effect on health and general well-being. However, despite the fact that colds and flu are considered relatively benign diseases, preventing or alleviating the course of these diseases is not an easy task. Once in the body, the virus multiplies rapidly, provoking a number of symptoms: rhinitis, cough, headache, loss of strength and loss of general tone, hyperthermia.

Today, people are increasingly in need of effective and convenient drugs that will prevent or minimize and alleviate the course of the disease.

There are still no drugs at the disposal of mankind that can cope with a viral infection with 100% efficiency. Today, antiviral drugs are imperfect, but their number and variety is growing, and the effectiveness is increasing every year.

Russian antiviral drug Kagocel- This is another domestic drug for colds, flu and acute respiratory diseases.

Most antiviral drugs sold in have a positive effect only when treatment is started early (on the 1-2nd day of the disease). Kagocel, in turn, is effective at any stage of the disease. It not only facilitates and shortens the course of the disease, but also significantly reduces the likelihood of complications. In addition, the drug is safe and does not cause side effects(with the exception of rare cases of allergic reactions). Therefore, it is approved for use by children over 3 years old.

Kagocel was developed by Nearmedic Plus (RF), established on the basis of the Research Institute of Epidemiology and Microbiology named after A.I. N.F. Gamalei RAMS. The drug was approved by the Ministry of Health and Social Development of Russia as a drug recommended for the prevention and treatment of acute respiratory viral infections, influenza, as well as for the treatment of pathologies associated with herpes virus infection. In addition, the drug was included in the list of vital and essential medicines, due to which it was included in the state system. procurement. Produced since 2005. It is released in pharmacies without a prescription.

Interferon inducers

Since the production of interferon is one of the first immune responses to virus infection, stimulators of the production of this protein occupy a special place among antiviral drugs.

Interferon inducers do not cause an immune response, and are not capable of causing an overdose. Once in the body, drugs of this group stimulate the production of interferons in optimal quantities.

Interferon inductors are divided into two groups: artificial and natural origin. The drug Kagocel, in turn, belongs to the second group. It stimulates the production of alpha, beta, and gamma interferons in the human body, which have a high antiviral effect.

The mechanism of action of the drug

Since in the preparation of the drug the active substance binds to the cellulose base, Kagocel is practically not absorbed in the digestive tract (no more than 20% of the active substance is absorbed).

Kagocel enhances the activity of interferons (specific cellular proteins that protect the body from viruses) in the body.

Influencing the body, Kagocel induces the production of interferons in the body, which have a pronounced antiviral effect. The action of the drug lasts 5-7 days. Due to the long-term effect of the drug, it is convenient to use it for the prevention of acute respiratory diseases and influenza in small doses, short courses and at any time of contact with the spreader of the disease.

Kagocel enhances the production of interferon in all cells that are part of the antiviral immunity system: in and B-cells, macrophagocytes, granular leukocytes, fibroblasts, endothelial cells.

However, the action of Kagocel is not limited to the induction of the production of interferons. The drug also stimulates the release of cytokines, activates cellular immunity and natural killers.

The effect of the drug on the body lasts an average of 5 days, during which the produced interferon circulates in the circulatory system. At the same time, the active substance accumulates in the intestine 4 hours after ingestion. After a single use of the drug in a standard dose, the concentration of interferon in the blood increases significantly, reaching a maximum after two days. The maximum concentration of interferon in the blood persists for 2-3 days.

According to the results of numerous clinical trials, with repeated daily use of the drug, the active substance enters various organs and tissues in uneven proportions. A day after entering the body, most of the active substance is concentrated in the liver. Also, in small concentrations, the drug accumulates in the lungs, spleen, kidneys, thymus and lymph nodes. Least of all, the drug accumulates in muscle tissue, heart, adipose tissue, brain and blood. When taken orally, approximately 20% of the active substance enters the bloodstream. In the blood, 47% of Kagocel binds to blood lipids, 37% to proteins, and 16% circulates in a free form. Kagocel molecules are quite massive, so it does not penetrate the blood-brain barrier, which prevents it from entering the brain. The drug is excreted mainly through the digestive tract. Approximately 88% of the active substance is excreted from the body 6-7 days after the completion of the course of treatment. At the same time, 90% is excreted through the gastrointestinal tract, and 10% through the kidneys. Excretion of the drug through the lungs has not been established.

Indications

• Kagocel is indicated for adults for the treatment of viral infectious diseases, as well as for the prevention of colds, flu and other acute respiratory infections, for the treatment of diseases associated with herpes virus infection;
• for children over 6 years of age, the drug is indicated for the prevention and treatment of influenza, colds and other acute respiratory diseases;
• Children 3-6 years old are indicated for the treatment of influenza, colds and other acute respiratory infections.

Contraindications

• hypersensitivity to the components of the drug;
• age up to 3 years;
• period of pregnancy;
• intolerance to glucose and galactose.

Dosage and administration

Kagocel is administered orally.

Adults
For flu, colds and other acute respiratory infections, take two tablets. 3 times a day for the first 2 days, then one tablet 3 times a day. The duration of the course is 4 days.
For the prevention of influenza, colds and other acute respiratory infections, 2 tablets are prescribed. 1 time per day for 7 days. Then spend a 5-day break, after which, if necessary, the 7-day cycle is repeated. The duration of the prophylactic course is determined by the attending physician, and ranges from 7 days to 3-5 months.
For the treatment of herpes virus infection, take 2 tablets. 3 times a day. The duration of the course is 5 days.

Children 3-6 years old
For flu, colds and other acute respiratory infections, take 1 table. 2 times a day for two days, then 1 table. per day. The duration of the course is 4 days.

Children over 6 years old
For flu, colds and other acute respiratory infections, take 1 table. 3 times a day for two days, then 1 table. 2 times a day.
For the prevention of influenza, colds and other acute respiratory infections, 2 tablets are prescribed. 1 time per day for a week. Then spend a 5-day break, after which the 7-day cycle is repeated. The duration of prophylaxis depends on various factors, and is determined by the attending physician. Prevention lasts from 7 days to 3-5 months.

Overdose

In case of an overdose of Kagocel, heavy drinking is indicated, followed by induction of vomiting. Medical advice is strongly recommended before resuming treatment.

Side effects

Rarely - an allergy to the components of the drug.

Interaction with other drugs

The drug Kagocel goes well with immunostimulants, antibiotics (complements their effect), and other antiviral drugs.

special instructions

The maximum therapeutic effect of the drug is achieved if treatment is started within a period not exceeding 3 days from the onset of the acute phase of the disease. For the prevention of influenza, colds and other acute respiratory diseases, the drug is used at any time, or after contact with the spreader of the disease.

Storage conditions

Keep out of the reach of children, at temperatures below 25 degrees.

Bird flu

One of the most promising methods of preventing avian influenza is vaccination and the use of interferon inducers.

Many scientists note that the above method deserves wider application in therapeutic and clinical practice, incl. in the prevention of influenza and acute respiratory diseases. At the moment, there is no vaccine against avian influenza, the effectiveness of which would be confirmed in practice. Kagocel, inducing the production of interferon in the body, enhances protection and promotes protection against all strains of viruses. Therefore, in the event of an epidemic of bird flu, this drug can serve as an effective means of preventing this dangerous pathology.

Prevention of influenza through vaccination provides protection only against the influenza virus, while the risk of ARVI is not reduced. Epidemics of influenza and SARS often occur simultaneously. Meanwhile, influenza vaccination is well combined with the use of interferon inducers, incl. Kagocela. Therefore, the complex application of the above methods provides more reliable protection against viral infection.

Kagocel for children

Today, this drug is widely used in the treatment and prevention of seasonal viral diseases in adults. But for children, as a therapeutic drug, it is indicated only from the age of 6, since clinical trials have not been conducted on children and pregnant women to date. In order to prevent influenza and SARS, the medication is allowed for children over 3 years old.

The drug affects the body of a child in the same way as it does on the body of an adult, tk. interferon begins to be produced in the body from the moment of birth. And Kagocel, in turn, simply stimulates the release of this protein in large quantities.

Interferon can provide great support to children during the SARS epidemic season. Therefore, interferon inducers such as Kagocel should not be neglected - it will alleviate the course of the disease and reduce the risk of complications without causing any side effects.

Evaluation of the effectiveness of herpes treatment

This study was conducted by the Central Research Laboratory of the Omsk State Medical Academy

The herpes virus is one of the most common microorganisms that infect the human body. According to official statistics, approximately 90% of people living in cities are carriers of herpes viruses of various forms.

The aim of the study was to evaluate the drug Kagocel in the treatment of herpes infection.

The study involved 146 people, among them 63 were men, 83 were women. Genital herpes was diagnosed in 115 patients, oral herpes - in 31. In the treatment, Kagocel was used in the form of tablets for oral administration (active substance in 1 table - 0.012 g).

The subjects were divided into three groups: the first group was prescribed exclusively Kagocel, the second - Kagocel in combination with

Judging by Yandex data, in January, about 400,000 Russians searched the Internet for information about the drug Kagocel. People were especially interested in the price and effectiveness of the product. It is easy to find out the cost, but with its medicinal properties- not so simple. Reliable evidence of the effectiveness of kagocel in the treatment of colds does not exist, says the president of the Society of Evidence-Based Medicine Specialists, MD. Vasily Vlasov.

What is kagocel?

Whether a new drug is beneficial when used as directed is determined by comparative clinical trials. This is a well known truth. Evidence-based medicine prefers the so-called. randomized clinical trials (RCTs), when groups of patients are randomly selected so that the chances of the one being treated and the control receiving the “blank” pill are equal. In modern evidence-based medicine, it is customary to base judgments on the effectiveness of a drug precisely on the results of RCTs. First RCT, then permission for use in medical practice. Kagocel underwent RCTs that were insignificant in terms of coverage of patients and give every reason to doubt their good quality.

Is Kagocel safe?

To clarify the safety of drugs in developed countries, a system of pharmacovigilance has been created. This is a system for collecting data on side effects that occur when taking a medicine and summarizing them. If dangerous side effects are detected that were not detected during clinical trials for any objective reason, the indications and contraindications of the drug are changed. Unfortunately, pharmacovigilance in Russia is, to put it mildly, in its infancy. We do not have any information about the safety of Kagocel. But there are doubts, and serious ones.

The kagocel molecule consists of two parts: carboxymethyl cellulose (CMC) and gossypol. CMC is a chemically rather inert substance. It is used, for example, in detergents so that they foam better. It also forms the basis of adhesives.

Gossypol is obtained from cotton. The drug is considered a medicine of natural origin. Formally, Kagocel is considered to be a derivative of gossypol obtained by attaching an inert molecule to it. But the trouble is that gossypol has the effect of long-term oppression of fertility in men and affects the reproductive function of women. It was even studied as a potential contraceptive, but the idea was abandoned due to toxic effects.

The sellers of Kagocel claim that gossypol is in a bound form in their preparation, and its toxicity is not of great importance. On mice, they say, checked. Mice seem to breed. But studies on the effect of the drug on people have not yet been published. And it is not known whether such are being conducted.

In the absence of such an important evidence base, a competent doctor will not recommend Kagocel to his patient.

Why is Kagocel sold without a prescription?

Russian legislation allows the Ministry of Health to allow the use of drugs that have not passed RCTs. Why this happened is a separate question. And the Ministry of Health from time to time allows domestic drugs to be used on the basis of an extremely weak evidence base. Apparently, in this way officials encourage domestic manufacturers: inferior drugs, but their own. Abroad, these drugs are never used.

In fairness, it should be noted that we have a number of "antiviral" drugs, which are called so because they stimulate the production of interferons in the body, that is, they stimulate the immune system. Unfortunately, all of them do not have serious scientific and practical evidence of effectiveness. But they bring a good profit, especially during the season of colds. The very idea of ​​stimulating immunity by producing interferon to fight viruses belongs to the middle of the 20th century. Today

With carboxymethylcellulose) - 12 mg;

potato starch - 10 mg;

calcium stearate - 0.65 mg;

ludipress (directly compressed lactose, which is a mixture of lactose monohydrate, povidone (kollidon 30) and crospovidone (kollidon CL)) - up to 100 mg.

Release form

In pharmacy kiosks, the medicine can be found in the form of biconvex round tablets of cream or Brown color with small patches. The contour cell blister contains 10 pieces. 1 plate is included in the carton box.

pharmachologic effect

Kagocel (INN - International Nonproprietary Name) is an antiviral drug that is a synthetic complex organic sodium salt obtained by synthesis from water-soluble Carmoxymethylcellulose and Cottonseed Polyphenol. That is, the biologically active component of the drug is based on a certain proportion plant compounds .

Interferon titer in serum increases gradually and reaches the maximum figures 48 hours after the use of the tablets. AT intestines the dynamics of accumulation of antiviral proteins is much higher - maximum production of interferon observed after 4 hours. Therefore, it is recommended to monitor the effectiveness of the drug by examining the contents of the lumen of the digestive tube and the activity of its cellular structures.

Therapeutic effect characterized as long-term, since the response of interferons persists for 4-5 days during which protective proteins continue to circulate in the bloodstream of the main and small vessels. Due to this property, the greatest efficiency in conservative treatment with a pharmaceutical preparation is observed when it is prescribed no later than the 4th day from the onset of the acute course of the infectious process.

Indications for use

• prevention of colds ;
• simple in the adult category of patients.

Contraindications

• increased individual sensitivity to the constituent components of a pharmaceutical product;
• period and ;
• hereditary or acquired intolerance medicinal product;
• age category of patients up to 3 years;
• enzymatic disorders digestive system - lactase deficiency, lactose intolerance, glucose-galactose malabsorption.

Side effects

Adverse effects from the use of the drug are extremely rare and are usually limited . However, if the patient observes any side effects active components of a pharmaceutical product, you should immediately seek the advice of a qualified doctor.

Instructions for use Kagocel (Method and dosage)

Tablets Kagocel, instructions for use

In the annotation, the manufacturer indicates that the drug should be used orally without chewing the tablet, but swallowing it whole. You can drink plenty of liquid, but do not keep it in your mouth for a long time. The dosage and duration of treatment are usually selected individually empirically, but there are also general therapeutic regimens that should be considered by the attending physician as practical recommendations.

How to drink for adults?

For therapeutic purposes with acute respiratory viral infections , or flu-like diseases are prescribed 2 tablets 3 times a day for the first 2 days, and the next 2 days, 1 tablet 3 times a day. The course dosage is 18 tablets, and the duration of treatment is 4 days. How to take - before meals or after - for an adult body is of no practical importance, since the absorption capacity of the biologically active components of the pharmaceutical preparation does not change with the intake of food into the cavity of the gastrointestinal tract.

The drug can also be used as preventive , preventive sanitation , which is carried out in 7-day cycles. The course is divided into two phases. The first, active, when 2 tablets are prescribed 1 time per day for 2 days, and the second, passive, is a 5-day break (the time during which the active ingredients are able to realize their therapeutic effects). Then, if necessary, you can repeat the preventive course of treatment.

Instructions for use for children

In the age category 3 to 6 years old - 1 tablet 2 times a day for the first 2 days, and for the next 2 days, 1 tablet 1 time per day. In total, the children's therapeutic course for the smallest is 6 tablets for a duration of 4 days.

Aged over 6 years appoint 1 tablet 3 times a day for the first 2 days, and in the next 2 days - 1 tablet 2 times a day. Accordingly, the duration of conservative rehabilitation has not changed and is 4 days, and the dosage of the pharmaceutical preparation has increased to 10 tablets.

The drug can be used with a preventive purpose and in pediatric practice. The biphasic regimen of the drug is maintained, however, the dosage is reduced to 1 tablet 1 time per day for the first 2 days.

How to take Kagocel with herpes?

Since the pharmaceutical action of Kagocel extends to viruses and immune system, respectively, the drug can be used by the adult category of patients not only for the treatment of colds of viral etiology, but also for the elimination of unpleasant herpes sores. How to drink tablets for herpes - 2 tablets are prescribed 3 times a day for 5 days. Heading dose - 30 tablets.

Overdose

As well as side effects, the clinical state of overdose is very rare and is accompanied by bouts of nausea and pain in the upper abdomen. In the event of the occurrence of these symptoms, it is recommended to clear the gastrointestinal tract from Kagocel tablets using artificially induced vomiting. Further, plentiful drinking and some other elements are prescribed. detoxification therapy .

Interaction

Clinically significant interactions have not yet been identified and are not described in the medical literature.

Terms of sale

The annotation to the drug claims that the tablets are freely available in pharmacy kiosks, that is, you can purchase the drug without an appropriate prescription.

Storage conditions

Keep the tablets out of the reach of children at a temperature not exceeding 25 degrees Celsius.

Best before date

special instructions

Is Kagocel an antibiotic or not?

The drug has strong antimicrobial, antiviral and immunomodulatory therapeutic effects, from which tablets can be perceived by ordinary people as. But from the side of clinical pharmacology, this is not entirely true, because in determining this group of pharmaceutical products, the key is the natural or semi-natural origin of the active ingredients. Kagocel, in turn, is synthetic derivative plant components, which allowed research scientists to combine the best qualities of anti-cold drugs in one tablet.

Kagocel's analogs

Coincidence in the ATX code of the 4th level:

Also, many pharmaceutical preparations are considered as analogs of Kagocel, which do not have an identical therapeutic effect, but are similar in the final result to an anti-cold antiviral drug.

Which is better: Kagocel or Ingavirin?

is a pharmaceutical preparation popular in winter, characterized by a pronounced antiviral effect against the most common pathogens of acute respiratory diseases, such as influenza A and B viruses and influenza couple, respiratory syncytial group of viruses, and many others. Its mechanism of action is based on the ability of biologically active components to influence reproductive processes and resumption of malicious agents. Also, the drug in the form of capsules is credited with a strong anti-inflammatory effect on the human body.

Undoubtedly, the pharmaceutical preparation is effective in the course of conservative rehabilitation of colds with a confirmed origin of the pathogen, however, as non-specific therapy when it is not possible to establish the etiological component of the pathology, the use of Ingavirin is not rational. Kagocel also wins in another way, namely preventive measures , because the drug is actively used to prevent the development of respiratory infections in the winter, which, unfortunately, Ingavirin cannot boast of.

Which is better: Kagocel or Arbidol?

, like Kagocel, is an antiviral drug, the therapeutic expediency of which is to increase the production of natural interferon, which opposes the invasion of pathological agents. In addition, the active components of the drug stimulate cellular and humoral immune responses, which positively affects the body's resistance to viral respiratory infections.

The list of side effects of Arbidol is as short as that of Kagocel, but unlike the latter, the pharmaceutical preparation is included in list B (registry of medicines, the appointment of which should be made with extreme caution, since unforeseen complications may develop when they are used without careful medical supervision), which in itself is alarming. If a decision is made to undergo conservative therapy or preventive rehabilitation "on the legs" (without an official sick leave), then Kagocel should definitely be chosen.

Which is better: Kagocel or Amiksin?

It is an effective synthetic interferon inducer, that is, the mechanism of action is similar to Kagocel tablets, since the drug increases the formation of an active antiviral agent by intestinal epithelial cells, hepatocytes, and some fractions of lymphocytes. A distinctive feature of Amiksin is the speed of attack. therapeutic effects , a mild immunomodulatory effect is observed already 4-24 hours after taking the drug. Accordingly, its use is more rational in urgent conservative rehabilitation adult patients.

AT pediatric practice the pharmaceutical drug has not gained such wide popularity, since the annotation contains a contraindication to the use of tablets Amiksin up to 7 years old. This means that in the treatment of children of the younger age segment, preference should be given to Kagocel, the use of which can be started as early as 3 years.

Kagocel or Ergoferon - which is better?

Ergoferon is a drug with an unusually wide spectrum of therapeutic action, which, in addition to selective antiviral and immunomodulatory effects, includes antihistamines and anti-inflammatory Components. The clinical rationality of the use of a pharmaceutical product has been proven on many counts. So, for example, the list of pathogens of respiratory infectious diseases that are defeated after using Ergoferon tablets is much larger than that of Kagocel.

Separately, it should be noted that Ergoferon can be used both in therapeutic practice for adult patients and in pediatrics, starting from the age of 6 months. Based on these facts, the pharmaceutical preparation can be recognized as better than Kagocel, but the price of analogues of this level is, of course, higher.

Kagocel for children

The pharmaceutical preparation is actively used in pediatric practice, since its therapeutic spectrum covers one of the widest parts of pediatric nosology. Acute respiratory diseases of infectious, bacterial or any other origin occur all the time, because Kagocel is prescribed for children from the age of 3. Annotation to the drug assures the safety of such an early use of the drug, and grateful reviews from parents only confirm this fact.

How to take children, you can find out in the paragraph with the instructions, where the exact dosages of the pharmaceutical preparation for different ages are indicated. You should also pay attention to the possibility of prophylactic use of the drug to prevent the development of colds and acute respiratory diseases, which in childhood are found everywhere.

Kagocel and alcohol

According to the mechanism of action and pharmacokinetic abilities of the active components of Kagocel, the drug does not directly interact with the components of alcoholic beverages. But endogenous interferons , produced under the influence of antiviral tablets, have a negative, inhibitory effect to the central nervous system. That is, immune agents are capable of provoking the development of certain psychological and neurological disorders (especially often - retinopathy , neuropathy , lingering and so on).

As a rule, such adverse effects of conservative treatment are manifested asthenic disorders – excessive fatigue, weakness, reduced attention, impaired ability to concentrate However, against the background of an acute respiratory disease, such side effects are not noticed, because they are similar to the clinical symptoms of almost any catarrhal nosological unit.

If you mix alcohol and Kagocel, then such manifestations are mutually enhanced (the effect of alcoholic beverages on the central nervous system of a person is characterized by an inhibitory effect), therefore, at least 5 days must pass between the end of conservative treatment and the use of alcoholic beverages.

During pregnancy and lactation

Reliable clinical studies on the effect of the active components of a pharmaceutical preparation on the body of a woman and a child developing in her womb have not been conducted, therefore the decision to use the drug is made on an individual basis. Most practitioners are inclined to replace pills with other antiviral drugs during pregnancy and include this condition of the female body in contraindications to the use of Kagocel. A similar opinion of qualified specialists about breastfeeding- If possible, avoid the use of this medicinal product.

Reviews about Kagocel

The antiviral pharmaceutical preparation is widely popular among patients of pulmonology and therapeutic departments. The reason lies in the peculiarities of the mechanism of action of Kagocel and, of course, in its clinical effectiveness, because for a relatively small conservative course of treatment of 7 days, the drug allows you to completely eliminate acute respiratory disease and significantly improve the quality of life in winter.

Separately, it is worth noting the reviews of doctors about Kagocel, since qualified medical specialists recommend using these tablets primarily for preventive sanitation of the bronchopulmonary system. The active ingredients make it possible to increase the production of interferon several times, that is, they supply the body with methods to fight against viruses and other harmful agents, which has such a significant therapeutic effect of the use of a pharmaceutical preparation.

Tablets are used not only for the adult category of patients, but also for children, Kagocel reviews on forums dedicated to pediatric topics should also be taken into account when we are talking about this drug. Parents' reviews, as a rule, are full of positive emotions and grateful words, because Kagocel is used from the age of 3 years, so the child can safely go to kindergarten or elementary school without fear of another respiratory infection or viral invasion.

Kagocel is approved by most parents and for the absence of severe side effects. Conservative treatment with the drug is almost painless, if you do not take into account possible minor allergic reactions . Also, the release form does not have an unpleasant odor or taste, that is, it will not be necessary to make special efforts to sanitize even the youngest children.

Kagocel price, where to buy

Like the cost of antiviral analogues, the price of Kagocel may vary from the place of purchase of the pharmaceutical product. Russian Federation boasts a lower price category of the drug, because it is produced at its factories. Indicative is the price of Kagocel in St. Petersburg, which is about 180 rubles. In the capital, you can buy it for 200 rubles.

The price of Kagocel in Ukraine is much higher, because there is a need to transport the drug over long distances. A variation of the pharmaceutical product for adults can be purchased in the range from 150 to 180 hryvnia. But how much does a children's Kagocel cost in the nearest pharmacy, it is recommended to find out in advance, since its use in pediatric practice is somewhat narrower, which can adversely affect the price.

• Internet pharmacies in Russia Russia
• Internet pharmacies of Kazakhstan Kazakhstan

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Note!

Information about medicines on the site is a general reference, collected from publicly available sources and cannot serve as a basis for making a decision on the use of medicines in the course of treatment. Before medicine use Kagocel surely consult with the attending physician.

Reviews

Razvodilovo, zero effect

Antiviral agent Tiloram. I will share my experience about this drug, maybe it will help someone. Due to my age, I’m probably 54 years old, I have a rather weak immune system and I often, especially in the cold season, get sick with ARVI and acute respiratory infections, of course, I was treated a lot from expensive to more budgetary ones: Kagocel, Arbidol, Ingoverin and others, some helped quickly, which are not very good, we can say it went away on its own. I constantly change the means, so that there is no addiction, any drug helps more effectively if you use it for the first time. Once again, having fallen ill at the pharmacy, I bought a new drug, I had not used it before with an average price category ... not very cheap, but not too expensive either. It is produced by our domestic company Ozone. Only six tablets, medium size, in a small plastic jar, tightly closed with a cotton swab inside. The regimen is not complicated, sometimes you need to take a pill every 6 hours, but not here .. one a day for the first two days and then generally one every two days. I took these pills according to the instructions, it became easier for me already on the third day, this is quite fast compared to other similar drugs for my body, but of course there is also a lot of warm drinking and bed rest. Overall impression - I'm satisfied. In the approach of winter and cold weather, I will definitely use tiloram for the purpose of prevention, I will definitely unsubscribe.)

Tatyana, so these are different things. Paracetamol is symptomatic - knocks down the temperature. Kagocel stimulates the immune system to fight the virus. acts on the cause, not the effect.

I read reviews and fuck ...))) How can paracetamol and other antipyretics be compared with Kagocel .. People, don't be stupid already ...

Maryana, Kagocel is indicated for viral infections and has an antiviral effect. Before starting treatment, it is necessary to establish the nature of the infection - a virus or a bacterium. To do this, you need to do an analysis. If your child had a virus, then an antiviral should have helped. Kagocel is quite effective in treatment. Since you have a cough, it can be assumed that the child originally had a bacterial infection - in such cases, no antiviral will help. It was necessary to start treatment with antibiotics. And in general, self-medication is the last thing. what to do, you need to see a doctor.

Kristina September 4, 2015, 17:17

Kagocel is a very good drug, I didn’t find anything better for myself, I take it for preventive purposes, so I practically don’t get colds and flu, I think that you need to worry about your body in advance, and not when it gets hot. Although I know that many are treated with it, it is also very effective. But, unfortunately, Kagocel is not a panacea, and a priori it cannot be ideal for absolutely everyone. The instruction warns that it is contraindicated for people with hypersensitivity to the components of the drug, apparently the reason for Marusya's ailment is precisely this.

Be careful with this drug. After taking 1 tab after 10 minutes, I became red like cancer, my heart jumped out of my chest, called an ambulance, as a result, after prednedozol and a medical doctor, they took me to the hospital. On the way, the redness disappeared, but they wanted to leave it for examination, wrote a written refusal. However, since then I have been taking new drugs only 1/4 each and looking at the reaction ....

All amixins, arbidols, interferons, ingavirins, viferons and kagocels are personal business projects of officials who cut money on the sly. Selling these "drugs" is impossible in normal countries, because they will NEVER be entered into the registry without clinical trials. We also built a packing machine, made tablets and sell it to anyone you want. At best, they do not harm, but certainly do not cure. Think about why you drink all sorts of incomprehensible and at the same time insanely expensive chemicals that have absolutely no effect.

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